Recently Published Articles
Lipopolysaccharide Prompts Oxidative Stress and Apoptosis in Rats’ Testicular Tissue
Abstract:
Lipopolysaccharide (LPS) is a component of the outer membrane of gram negative bacteria. LPS challenging allows switching transcription of proinflammatory cytokines on via over stimulation of Toll-like receptors (TLRs) signaling pathway with subsequent pathogenic inflammatory response. We investigated the possible reproductive toxicity of LPS in male Wister albino rats. Oxidative stress markers, antioxidant status and caspase-3 activity were analyzed in testicular tissues of rats exposed to either saline or LPS (4 mg/kg BW, ip; 0.18 of the LD50). The samples were collected at 6 h and 72 h after injection of LPS. A significant reduction in testicular reduced glutathione (GSH), glutathione-S-transferase (GST) and superoxide dismutase (SOD) was observed at 72 h compared to control group. Total antioxidant capacity was decreased at 6 h with additional significant reduction at 72 h. Catalase activity was reduced significantly at both 6 and 72 h. Malondialdeh...
Statins and Lung Cancer: A Review of Current Literature
Abstract:
Cardiovascular disease and lung cancer are two of the most common causes of death in the United States. The cardioprotective benefits of statin class drugs is predominantly mediated through the inhibition of 3-hydroxy-3-methylglutaryl CoA (HMG-CoA) reductase, decreasing available mevalonate, and thus limiting in vivo cholesterol biosynthesis. Mevalonate and its metabolites have significant roles in cellular membrane synthesis, which is dysregulated during tumorigenesis, and is therefore a potential source for anti-tumor effects of statins. Similarly, dysregulation of cellular signaling is a hallmark of tumorigenesis. In vitro studies of EGFR, RAS, and AKT signaling pathways in cancer cells can all be reformed back to states more indicative of normally functioning cells when treated with statins. Statins have also been shown to exert beneficial properties in the presence of chemotherapeutic medications and radiation therapies by modulating the deleterious effects ...
Electrospun Biopolyesters: Hydrophobic Scaffolds with Favorable Biological Response
Abstract:
This article reviews electrospun biopolyester scaffolds, focusing on surface hydrophobicity, cell response, and applications in tissue engineering.
First Record Fungi for Iraq
Abstract:
44fungal species were isolated from plant parts submerged in Al-Huwaiza marsh within Iraqi borders, and 7 new first records fungi in Iraq were isolated too, which have been illustrated and described as follows:- Carbosphaerella leptosphaeriodes, Curvularia lunata var.aria, Graphium sp., Helicascus kanaloanus, Leptosphaeria obions, Stagnospora sp. and Ulocladium tuberculatum, Carbosphaerella leptosphaeriodes, Curvularia lunata var. aeria, Graphium sp., Helicascus kanaloanus, Leptosphaeria obions, Stagnospora sp., Ulocladium tuberculatum.
Memory: A Universal Concept but Limitedly Known.
Abstract:
A broad essay surveys the concept of memory across disciplines. It distinguishes short‑ and long‑term processes and reflects on measurement limits and open questions.
Hepatic Tuberculosis of Pseudotumor Form
Abstract:
Tuberculosis involving the liver in the absence of active pulmonary tuberculosis is very rare. The inflammatory pseudotumoral form is an entity difficult to diagnose. We report a case of an inflammatory pseudotumor of the liver due to tuberculosis, who didn’t underwent hepatectomy because of the size of the tumor. The diagnosis of tuberculosis was made on biopsy and Polymerase Chain Reaction (PCR).
Journal of Diseases
Abstract:
An editorial introduction to the Journal of Diseases outlines its scope across infectious, chronic, and emerging conditions. It emphasizes integrative research, methodological rigor, and open access to accelerate translation into public health and clinical practice.
The Harmonizing Power of Poetic Language, Between Mimesis and Catharsis
Abstract:
Rationally, to clarify the genesis and the resonant power of the (poetic) language implies two pluridisciplinary perspectives, namely: a) the contributions of semiotics, phonology and linguistic, neuro-physiology and biophotonics, in order to justify the mimetic dimension of the words by its sonorous signifier; b) the contributions of psycho-logics and psycho-analysis connected to literary hermeneutics, able to explain how the mental images and thoughts are becoming emotional states by the "lighted" signified of the words. The both perspectives are (auto)referentially connected – for a more explicit illustration – to the poetic / metaphoric language used by the authors. In this integrative way, the paper is complex, acknowledging the assumption of sufi thinkers that our words are "sounds full of light".
Insufficiency of Vitamin D in adolescents of the South of Brazil
Abstract:
This article examines vitamin D insufficiency among adolescents in southern Brazil. It summarizes prevalence, potential determinants such as sun exposure and diet, and implications for bone health, calling for targeted prevention and screening strategies.
Effects of Water Replenishment from Yellow River on Water Quality of Hengshui Lake Wetland
Abstract:
Hengshui Lake Wetland is the only national wetland and bird nature reserve in the North China Plain. It plays an important role in maintaining the species diversity and ecological balance. In recent years, due to industrial and agricultural production, infrastructure and ecological environment construction and other reasons, the infiltration, runoff, evapotranspiration and other water balance elements was changed, which reduced runoff into the lake. In order to ease the tense water resources situation in the region, Hengshui Lake is replenished each year by Yellow River water. Although Diversion Yellow River Wetland has made direct water supply protection, but also affected the ecology and environment of Hengshui Lake wetlands. In order to understand how artificial water diversion can affect the ecological environment of natural lakes, this paper analyzes the effects of artificial water storage on the water quality of the lake by using the measured data of water s...