Recently Published Articles
Profile of Similarity of Electron Withdrawing Structure Towards Analgesic-Anti-Inflammatory Activity of The Novel Isatin Analogue: Design and Implementation of Phase I Drug Discovery
Abstract:
Isatin (1H-indole-2,3-dione ) and derivatives demonstrate a diverse array of biological activities. Isatin and 5-halo derivatives has reacted to form the schiff’s bases , mannich bases and friedal craft alkylation’s to form C-C, C-N, C=N bonds. From the spectral studies, isatin has undergoes reaction at C-3 and N-1 position and synthesized lead in present schme and seen the similarity of structure and analgesic-anti-inflammatory activity.
Polysaccharide Transglycosylases: A Survey of Assay Methods
Abstract:
Polysaccharide transglycosylases (PTGs) are a unique group of glycoside hydrolases playing important roles in the formation and modification of plant and fungal cell walls. Their action involves cutting the molecule of the polysaccharide substrate at the glycosidic bond, followed by transfer of the newly formed reducing-end fragment to the non-reducing end of another polysaccharide molecule, with the formation of a new glycosidic bond. As there is no net increase in the number of reducing ends in the system, conventional reductometric methods used to assess the activity of glycoside hydrolases are ineffective. Since the PTGs participate in vital processes, such as the elaboration of cell walls in plants and fungi, and are not present in animal cells, they are considered as possible targets for future specific fungicides and herbicides. Biochemical studies of PTGs, as well as the search for their inhibitors, require the availability of convenient and efficient met...
Post Abortion Contraception Model: A Comprehensive Package for Improving Safe Abortion Care in Developing Countries
Abstract:
Despite liberal abortion laws and wide availability of contraceptives in Ghana, declining Post Abortion Contraception remains a public health challenge due to early unplanned pregnancies and recurrent abortions. The development of this model was therefore to address challenges of low contraception following induced abortion in health facilities within the capital city of Ghana. The development of this model was an outcome of a nested study title:
Prevalence of Non-Fistulous Urinary Incontinence among Nonparturient Women in A Tertiary Hospital
Abstract:
To determine the prevalence and risk factors of non-fistulous urinary incontinence (UI) among non-parturient women at University College Hospital, Ibadan, Nigeria. A hospital based cross sectional study of 500 non-parturient women presenting with non- fistulous gynaecological symptoms at the University College Hospital, Ibadan. An interviewer administered questionnaire was used to obtain information. Data were analyzed using SPSS version 20. Data analysis involved descriptive statistics, bivariate and multivariate analysis to d...
The Efficacy of Behavior Management for Depression in Dementia Patients: A Systematic Review and Meta-Analysis
Abstract:
Dementia is a serious brain disease that impacts negatively in several areas of patient’s functioning. Depression has a strong link with dementia and is part of the behavior and psychological symptoms (BPSD). Behavior management for depression is recommended as a first-line psychological treatment for dementia patients. However, there are no systematic reviews examining the efficacy of behavior management for depression in dementia. To examine the efficacy of behavior management (BM) for depression in dementia patients. Five electronic databases were searched (1999 to 2015) for randomized controlled trials (RCTs) which were selected according to eligibility criteria. Data was pooled, quality ...
Ordeals of Sexually Violated Women and Access to Comprehensive Healthcare: A Case Study of Victims of Sexual Violence in North Kivu, Eastern Congo
Abstract:
The impact of sexual violence in any community is extremely devastating and women in the Eastern part of the Congo are no exception. Sexual violence not only affects the health of women, but it impacts their social life within the community too. The study aims to investigate the experiences of female victims of sexual violence in accessing medical care in North Kivu. An interpretive, phenomenological approach was used for this inductive and qualitative study. In-depth informant interviews were the main data collection tool. Open-ended questions were used during the interviews in order to garner more information from the interviewees. Heidegger’s approach was utilized in analyzing the collected ...
Endocrine Disrupting Chemicals: Epigenetic Relevance and Mechanisms
Abstract:
Genetics alone cannot thoroughly expound the environmental impact on the molecular complexity of the endocrine system. Epigenetic-induced alteration in gene expression has emerged as a way in which environmental compounds may exert endocrine effects. The environmental compounds that interfere with normal endocrine signaling are one of the largest classes of toxicants we are exposed to, on a daily basis. Epigenetic mechanisms, mainly the methylation of DNA and the modification of histones, lead to differentiated activation and deactivation of genome domains creating phenotype plasticity and divergent endocrine function among populations and individuals, as well. The issues examined in the present review are related to environmental epigenetics, and more precisely, the epigenetic-mediated modulation and relevance of endocrine disrupting chemicals, focusing on three broad aspects: 1) persistence of EDs, 2) their major hormonal effects and 3) the potential of compou...
Appropriate Conservation Machinery for Mungbean Cultivation in the Southern Region of Bangladesh
Abstract:
The study was conducted at Mundopasha, Wazirpur, Barisal during Rabi season of 2017 for testing, adoption and popularization of different conservation machinery (CA) such as zero till planter (ZT), strip till planter (ST), bed planter (BP) and power tiller operated seeder (PTOS) along with conventional tilling and of sowing method for planting of mungbean (BARI Mung-6). The soil type was loamy-sand with bulk density 1.41 g/cc. The effective field capacities of ZT, ST, BP, PTOS and power tiller were found to be 0.104, 0.109, 0.084, 0.109, and 0.074 ha/h, respectively. The field efficiency of ZT, ST, BP, PTOS and power tiller were estimated as 74.68, 76.47, 75.84, 78.16 and 71.52%, respectively. Significantly the highest mungbean grain yields were found from ZT and ST planted plots than those of other plots. Significantly the lowest grain yield was obtained from conventional tillage and broadcasting method. The highest benefit cost ratio (BCR) was obtained from ST p...
Morpho-biochemical Identification and Antimicrobial Susceptibility Testing of Bacterial Isolates from Chicken Eggs in District Faisalabad
Abstract:
Microorganisms are the main cause of food-borne illness in humans that may occur by consuming unhygienic products from poultry and other sources. With the passage of time bacterial resistance to antibiotics is ever-increasing which necessitates development of new antibiotics. One of the most obvious reasons of antimicrobial resistance in human-beings is the consumption of contaminated food with microbes. The aim of present study is to isolate, identify and characterize the food-borne pathogens from chicken eggs. For this purpose, a total of 240 egg samples were collected from eight different towns of Faisalabad. Samples were collected from egg surface, yolk, albumin and egg tray. Isolation, identification and characterization of commonly occurring egg borne pathogens including
Sulfonamides: Historical Discovery Development (Structure-Activity Relationship Notes)
Abstract:
Sulfonamide group is a magic group introduced as the main core for different bio-activities in drug industry. According to its substitutes, literature divides sulfonamide derivatives to antibacterial sulfonamides and non-anti-bacterial sulfonamides. As Data was collected from different sources such as Drug Bank.com and Pubchem.com databases and then was analyzed, we found that these compounds are different in their pharmacokinetics and pharmacodynamics; in addition to their sulfa cross allergy property. We presented these differences from these compounds changes in their chemical structure, in a way to build a solid base that can be depended on for developing new drugs from these compounds that interact with different receptors.